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Complexation of L-Lactate with Boronic Acids: A Solution and Holographic Analysis

✍ Scribed by Felicity K. Sartain; Xiaoping Yang; Christopher R. Lowe

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
346 KB
Volume
14
Category
Article
ISSN
0947-6539

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✦ Synopsis

Abstract

Boronic acids have been used as receptors for the detection of diols and α‐hydroxy acids. The incorporation of 3‐acrylamide phenyl boronic acid (3‐APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L‐lactate. However, it was also found that the use of 3‐APB resulted in the sensor being responsive towards a number of other compounds containing two hydroxy groups. This report details the further investigation into the reaction between L‐lactate and three boronic acid‐based receptors, both in the holograms and in solution, in order to establish the mechanism of binding. A novel boronate receptor is proposed based on this understanding.

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