Complexation of basic amino acids by water-soluble calixarene sulphonates as a study of the possiblemechanisms of recognition of calixarene sulphonates by proteins

✍ Scribed by Nathalie Douteau-Guével; Anthony W. Coleman; Jean-Pierre Morel; Nicole Morel-Desrosiers

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 152 KB
• Volume: 11
• Category: Article
• ISSN: 0894-3230
• DOI: 10.1002/(sici)1099-1395(1998100)11:10<693::aid-poc18>3.0.co;2-8

✦ Synopsis

The interactions of calixarene sulphonates with the basic amino acids arginine and lysine were studied by 1 H NMR spectroscopy. Strong electrostatic binding occurs for calix[4]arene sulphonate with both lysine and arginine at pH 1 and 5. For the higher calixarenes, only weak interactions at the faces of the flattened macrocycles occur. This binding is in contrast to the inhibition of protein-protein interactions by the calixarenes where the calix[6]arene and calix[8]arene sulphonates show much stronger effects.