Complex translocation t(3;9;22)(q21;q34;q11) at diagnosis is a negative prognostic index in chronic myeloid leukemia
โ Scribed by Gabriele Buda; Enrico Orciuolo; Sara Galimberti; Edoardo Benedetti; Francesco Caracciolo; Giulia Cervetti; Giovanni Carulli; Federico Papineschi; Mario Petrini
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 122 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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## Abstract __RUNX1__ (previously __AML1__) is involved in multiple recurrent chromosomal rearrangements in hematological malignances. Recently, we identified a novel fusion between __RUNX1__ and __LPXN__ from an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22). This translocation genera
## Abstract Chronic myeloid leukemia (CML) is characterized by the presence of a t(9;22)(q34;q11.2), which leads to the wellโknown BCRโABL1 fusion protein. We describe a patient who was diagnosed clinically with a typical CML but on cytogenetic analysis was found to have a t(9;22)(p24;q11.2). Chrom