Complex relationship between Parkin mutations and Parkinson disease
✍ Scribed by West, Andrew ;Periquet, Magali ;Lincoln, Sarah ;Lücking, Christoph B. ;Nicholl, David ;Bonifati, Vincenzo ;Rawal, Nina ;Gasser, Thomas ;Lohmann, Ebba ;Deleuze, Jean-François ;Maraganore, Demetrius ;Levey, Allan ;Wood, Nick ;Dürr, Alexandra ;Hardy, John ;Brice, Alexis ;Farrer, Matt
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 96 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Parkin, an E2‐dependent ubiquitin protein ligase, carries pathogenic mutations in patients with autosomal recessive juvenile parkinsonism, but its role in the late‐onset form of Parkinson's disease (PD) is not firmly established. Previously, we detected linkage of idiopathic PD to the r
## Abstract A multiethnic series of patients with early‐onset Parkinson's disease (EOP) was studied to assess the frequency and nature of __parkin__/PARK2 gene mutations and to investigate phenotype–genotype relationships. Forty‐six EOP probands with an onset age of <45 years, and 14 affected relat