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Complex patterns of ETS gene alteration arise during cancer development in the human prostate

✍ Scribed by Clark, J; Attard, G; Jhavar, S; Flohr, P; Reid, A; De-Bono, J; Eeles, R; Scardino, P; Cuzick, J; Fisher, G

Book ID
110072828
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
784 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar