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Complex heterocyclic structures - a challenge for computer-assisted molecular modeling

✍ Scribed by K. Mueller; H. J. Ammann; D. M. Doran; P. R. Gerber; K. Gubernator; G. Schrepfer

Publisher: Wiley (John Wiley & Sons)
Year: 2010
Weight: 604 KB
Volume: 97
Category: Article
ISSN: 0037-9646
DOI: 10.1002/bscb.19880970806

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✦ Synopsis

Computer-assisted molecular modeling in the pharmaceutical research environment is repeatedly challenged to cope with diverse and often complex heterocyclic structures. Such systems may contain any type of strained fragments, unsaturated hetero-functionalities, heterorings with extended pi-conjugation, accumulations of heteroatoms, bridged polycyclic subunits, macrocyclic rings, and/or any combination thereof.

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