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Complex cadherin expression in human prostate cancer cells

✍ Scribed by Marion J.G. Bussemakers; Adrie Van Bokhoven; Kyoichi Tomita; Cornelius F.J. Jansen; Jack A. Schalken

Publisher: John Wiley and Sons
Year: 2000
Tongue: French
Weight: 174 KB
Volume: 85
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(20000201)85:3<446::aid-ijc23>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

Changes in cell-cell interactions are critical in the process of cancer progression. Likewise, it has been shown that loss of expression of the cell adhesion molecule E-cadherin is associated with grade, stage, and prognosis in many carcinomas, including prostate cancer. Impaired E-cadherin-mediated interactions result in an invasive phenotype; however, the mere loss of cell-cell contact and communication is not the sole explanation for the observed correlation between loss of E-cadherin-mediated adhesion and poor clinical outcome. Using a degenerate cloning strategy for sequences that are highly conserved between the various cadherins, we found several other cadherins (N-and P-cadherin and cadherin-4, -6, and -11) to be expressed in human prostate cancer cells. Our data suggest that besides loss of E-cadherin function, also (upregulation of) expression of other cadherins is involved in the acquisition of an invasive and/or metastatic phenotype. Especially, changes in the expression of N-cadherin and cadherin-11 may play an important role in prostate cancer progression.

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