Complete nucleotide sequence of the AIDS virus, HTLV-III

✍ Scribed by Ratner, Lee; Haseltine, William; Patarca, Roberto; Livak, Kenneth J.; Starcich, Bruno; Josephs, Steven F.; Doran, Ellen R.; Rafalski, J. Antoni; Whitehorn, Erik A.; Baumeister, Kirk

• Book ID: 109737873
• Publisher: Nature Publishing Group
• Year: 1985
• Tongue: English
• Weight: 908 KB
• Volume: 313
• Category: Article
• ISSN: 0028-0836
• DOI: 10.1038/313277a0

✦ Synopsis

The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3'-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.