Complete Mouse Egg Activation in the Absence of Sperm by Stimulation of an Exogenous G Protein-Coupled Receptor
β Scribed by Grace D. Moore; Gregory S. Kopf; Richard M. Schultz
- Book ID
- 115597058
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 990 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0012-1606
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## Abstract Mammalian sperm possess guanine nucleotideβbinding regulatory proteins (G proteins) that are involved in signal transduction pathways leading to __zona pellucida__ (ZP)βmediated acrosomal exocytosis. We have previously examined ZPβG protein dynamics in mouse sperm homogenates, as well a
The fertilin a and b genes (Ftna and Ftnb, respectively) encode a sperm surface heterodimer that functions in sperm-egg fusion. They are the first identified members of a large gene family coding for multidomain membrane proteins (ADAMs) that include A Disintegrin And Metalloprotease domain. In this