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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

โœ Scribed by N. H. Hendrikse; A. H. Schinkel; E. G. E. De Vries; E. Fluks; W. T. A. Van der Graaf; A. T. M. Willemsen; W. Vaalburg; E. J. F. Franssen


Book ID
110003748
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
318 KB
Volume
124
Category
Article
ISSN
0007-1188

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In vivo benzodiazepine receptor occupancy by increasing doses of CL 218,872 has been evaluated in the baboon Papio papio, using (11C) RO 15-1788 as specific radioligand and positron emission tomography as external detection system. Although BZR heterogeneity has been previously demonstrated in the b