Complete design analysis of a continuous sterilizer for fermentation media containing suspended solids

Optimization of a novel headspace–solid-

Optimization of a novel headspace–solid-phase microextraction–gas chromatographic method by means of a Doehlert uniform shell design for the analysis of trace level ethylene oxide residuals in sterilized medical devices

✍ Michael P. DiCicco; Bridget Lang; Thomas I. Harper 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 513 KB

## Abstract Medical devices sterilized by ethylene oxide (EtO) retain trace quantities of EtO residuals, which may irritate patients' tissue. Reliably quantifying trace level EtO residuals in small medical devices requires an extremely sensitive analytical method. In this research, a Doehlert unifo