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Complete assignments of 1H and 13C NMR data for trypanocidal eremantholide C oxide derivatives

✍ Scribed by Dênia A. Saúde-Guimarães; Katia S. P. Perry; Délio S. Raslan; Egler Chiari; Alejandro F. Barrero; Juan E. Oltra

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
119 KB
Volume
45
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The chemical transformations of eremantholide C (1), a trypanocidal sesquiterpene lactone isolated from Lychnophora trichocarpha Spreng., gave five new oxide derivatives: 3′‐hydroxyeremantholide C (2), 1′‐formyleremantholide C (3), 1′‐carboxyeremantholide C (4), 1′‐carbomethoxyeremantholide C (5) and sodium 1′‐carboxylate of eremantholide C (6). The ^1^H and ^13^C NMR data of all these derivatives were assigned based on 1D and 2D techniques. The derivatives were evaluated against Y and CL strains of Trypanosoma cruzi. All of them were inactive against the Y strain. Compounds 2 and 5 displayed 100% activity on the CL strain while compounds 4 and 6 were partially active on the CL strain. Copyright © 2007 John Wiley & Sons, Ltd.

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