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Complementation between glucocorticoid receptor and lymphocytolysis in somatic cell hybrids of two glucocorticoid-resistant human leukemic clonal cell lines

✍ Scribed by Yeong -Seng Yuh; E. Brad Thompson


Book ID
112747322
Publisher
Springer
Year
1987
Tongue
English
Weight
774 KB
Volume
13
Category
Article
ISSN
1572-9931

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The application of glucocorticoids (GC') in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.RI-R5, isolated from the GC-sensitive human acute-1-cell-leukemic line,