Decreased antioxidant enzyme activity an
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Ya-Chun Yu; Chen-Ling Kuo; Wen-Ling Cheng; Chin-San Liu; Mingli Hsieh
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Article
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2009
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John Wiley and Sons
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English
β 207 KB
## Abstract MachadoβJoseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by polyglutamine expansion in the ataxinβ3 protein that confers a toxic gain of function. Because of the late onset of the disease, we hypothesize that the accumu