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Complementary PCAF–Coenzyme A Mutagenesis: Chemoenzymatic Synthesis of a Novel Enlarged Coenzyme A Analogue and Evaluation of Its Biological Activity

✍ Scribed by Dr. Leang Khim; Dr. Juan Han; Dr. Lynsey Willetts ; Dr. Kevin Brady; Dr. Pauline Gillece; Ouannassa Rached ; Prof. Dr. Neil R. Thomas; Dr. Eleni Stylianou

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 347 KB
Volume: 11
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.201000286

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## Abstract A series of novel N‐(substituted hetaryl)‐4‐aryl‐4‐oxobutanamides are designed, synthesis and evaluated for their activity against DGAT‐1 enzyme.