Complementary diastereoselective β-acylation of α-methylbutanamide
✍ Scribed by Takashi Houkawa; Tsuyoshi Ueda; Satoshi Sakami; Morio Asaoka; Hisashi Takei
- Book ID
- 103404378
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 164 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Chemoselective reduction of the carbonyl group in ~-acyl-N-[Bis(methylthio)methylene]alaninates la--¢ and phenylalaninates I d,e allowed for the diastereoselective synthesis of both the syn and the anti isomers of the corresponding N-protected ot,a-disubstituted [3-hydroxy-ot-amino esters 2. The ste
threo-a-Dibensylamino-B-hydroxyesters (2) have been synthesised with high diastereoselectivity through the NaBH reduction of a-dibenzylamino-B-oxoesters (4) and then tranformed into threo-a-amino-B-hydroxyac?ds. a-Amino-B-hydroxyacids are derivatives of primary importance both as enzymatic inhibito