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Complement-related serine proteases in tunicates and vertebrates

✍ Scribed by Misao Matsushita; Yuichi Endo; Masaru Nonaka; Teizo Fujita


Book ID
104358829
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
593 KB
Volume
10
Category
Article
ISSN
0952-7915

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✦ Synopsis


Serum mannose-binding lectin binds to pathogens in association with a serine protease termed MASP, and in this form, plays a crucial role in innate immunity by activating complement in a manner similar to activation via the classical pathway. MASP, C1r and C1s belong to the same family of serine proteases. In addition to its presence in advanced species, MASP also exists in primitive life forms such as tunicates and may be an evolutionary prototype of this family.


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