Complement reduces virus replication and myocardial injury in acute Coxsackie virus B3-induced myocarditis
β Scribed by Bobby Yanagawa; Caroline Cheung; Bruce McManus; Decheng Yang; Owen Spiller
- Book ID
- 116757124
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 88 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0161-5890
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## Abstract Myocarditis is a common cause of dilated cardiomyopathy, one of the most important single causes of heart transplantation. Coxsackie B viruses (CBV) are considered to be the principal etiological agents of viral myocarditis and direct virusβinduced damage to the heart tissue has been su
In murine myocarditis, it has been shown that natural killer cells first infiltrate the heart, followed by activated T-cells, which play an important role in the pathogenesis of the myocardial damage. In the same model of acute myocarditis, the repertoire of T-cell receptor (TCR) V p genes in infilt