Complement pores in erythrocyte membranes: Analysis of C8/C9 binding required for functional membrane damage

Crystal structure of CD59: implications

Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex

✍ Huang, Yuxiang ;Fedarovich, Alena ;Tomlinson, Stephen ;Davies, Christopher 📂 Article 📅 2007 🏛 International Union of Crystallography 🌐 English ⚖ 976 KB

Human CD59 is a small membrane-bound glycoprotein that functions as an inhibitor of the membrane-attack complex (MAC) of the complement system by binding the complement proteins C8 and C9. The crystal structure of a soluble construct of CD59 has been determined to 2.1 A resolution. When compared wit