✦ LIBER ✦

Complement-mediated cytolytic activity associated with cytomegalovirus complement-fixing IgM antibody

✍ Scribed by Dr. J. C. Booth; H. S. Mohammed

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 504 KB
Volume: 24
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890240312

No coin nor oath required. For personal study only.

✦ Synopsis

Cytomegalovirus-specific complement-fixing IgM (CMV CF-IgM) antibody was detected in 12/84 (14.3 percent) sera containing CMV-specific IgM. Higher titres were obtained by using a purified antigen preparation containing enveloped virus particles and membrane fragments when compared with a crude extract of infected cells, suggesting that the CF component of CMV IgM reacts predominantly with antigens on the surface of the infected cells. This also accounts for its complementmediated cytolytic activity. Neither CMV-specific non-complement-fixing IgM nor CMV-specific IgG demonstrates cytolytic activity.

📜 SIMILAR VOLUMES

Complement-dependent antibody-mediated c

Complement-dependent antibody-mediated cytotoxicity in the spontaneously diabetic BB/OK rat: association with β cell volume density

✍ Bernd Hehmke; Silke Lucke; Dieter Schröder; Ingrid Klöting; Klaus-dieter Kohnert 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 632 KB

The association of antinuclear antibodie

The association of antinuclear antibodies, antilymphocyte antibodies, and c4 activation among the relatives of children with systemic lupus erythematosus. preferential activation of complement in sisters

✍ THOMAS J. A. Lehman; John G. Curd; Nathan J. Zvaifler; Virgil Hanson 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 523 KB

## Abstract We studied 31 children with systemic lupus erythematosus (SLE) and 108 first‐degree relatives of the children to determine if HLA type, familial relationship to patient, or gender influenced the familial aggregation of SLE and the serologic and serum complement abnormalities associated