Complement in Type 1 (insulin-dependent) diabetes
β Scribed by G. Senaldi; B. A. Millward; M. J. Hussein; D. Pyke; R. D. G. Leslie; D. Vergani
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 95 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0012-186X
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π SIMILAR VOLUMES
Forty-four children with Type 1 (insulin-dependent) diabetes (aged 0.7-16.7 years) were observed from diagnosis for cytoplasmic islet cell antibodies and serum C-peptide concentrations. Islet cell antibodies were analysed by indirect immunofluorescence for both conventional IgG and complement-fixing
The role of complement in the pathogenesis of diabetes was studied in 31 Type 1 (insulin-dependent) diabetic children by assaying serum islet cell surface antibody, C3, C4 and serum complement-dependent antibody-mediated cytotoxicity. Nine of 21 islet cell surface antibody-positive children were wit
Patients with Type 1 (insulin-dependent) diabetes without proteinuria were studied to define those patients who will later develop persistent proteinuria (more than 0.5 g protein/24 h). Two investigations were performed; 71 patients were studied longitudinally for 6 years and another 227 patients we