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Complement functional tests for monitoring eculizumab treatment in patients with atypical hemolytic uremic syndrome

✍ Scribed by Cugno, M.; Gualtierotti, R.; Possenti, I.; Testa, S.; Tel, F.; Griffini, S.; Grovetti, E.; Tedeschi, S.; Salardi, S.; Cresseri, D.; Messa, P.; Ardissino, G.


Book ID
121852328
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
291 KB
Volume
12
Category
Article
ISSN
1538-7933

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Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com