COMPLEMENT-FIXING ISLET-CELL ANTIBODIES IN TYPE I DIABETES AND IN SUSCEPTIBLE PATIENTS WITH AUTOIMMUNE DISEASES
β Scribed by Betterle, Corrado; Caretto, Antonio; Tiengo, Antonio; Trevisan, Alfonso
- Book ID
- 123539715
- Publisher
- The Lancet
- Year
- 1980
- Tongue
- English
- Weight
- 275 KB
- Volume
- 315
- Category
- Article
- ISSN
- 0140-6736
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Forty-four children with Type 1 (insulin-dependent) diabetes (aged 0.7-16.7 years) were observed from diagnosis for cytoplasmic islet cell antibodies and serum C-peptide concentrations. Islet cell antibodies were analysed by indirect immunofluorescence for both conventional IgG and complement-fixing
We studied metabolic progression to IDDM in a cohort of adults who are ICA-positive and have associated autoimmune endocrine disease or circulating organ-specific autoantibodies (the Polyendocrine Study). Of the 186 individuals recruited 27 developed overt diabetes after a median follow-up of 4.5 ye