Complement diversity: a mechanism for generating immune diversity?

✍ Scribed by J Oriol Sunyer; Ioannis K Zarkadis; John D Lambris

• Book ID: 104298978
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 420 KB
• Volume: 19
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(98)01341-3

✦ Synopsis

Unlike mammalian species, several cold-blooded species have been shown to possess multiple forms of complement components. The multiple forms of C3 characterized in several fish species can bind with different specificities to various complement-activating surfaces. Here, Oriol Sunyer, Ioannis Zarkadis and John Lambris explore the possible advantages conferred by having multiple forms of individual complement proteins in a single organism.