A C7 cDNA probe detecting a TaqI restriction fragment length polymorphism has been used to examine the segregation of the "silent allele" (C7\*Q0) in two familial deficiencies. Carrier diagnosis in healthy children is possible when both parents are heterozygotes. Only one of these two families was i
Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families
✍ Scribed by Ö. Sanal; M. Loos; F. Ersoy; G. Kanra; G. Seçmeer; I. Tezcan
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 359 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0340-6997
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Objective. To describe a new kindred with Clq deficiency and to identify the molecular lesions responsible for complete functional Clq deficiency in this and 2 other previously described kindreds. Methods. The A-, B-, and C-chain genes of Clq were amplified by polymerase chain reaction, cloned, and
The complement system has been implicated in the pathogenesis of liver diseases. Human complement component C3 (C3) exists as 2 allotypes, fast (F) and slow (S). We conducted a study to address the influence of these alleles on ischemia-reperfusion (IR) injury and graft survival in liver transplant