Complement component C1q unaltered by ascorbate supplementation in healthy men and women

✍ Scribed by Carol S. Johnston

• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 222 KB
• Volume: 2
• Category: Article
• ISSN: 0955-2863
• DOI: 10.1016/0955-2863(91)90106-f

✦ Synopsis

In the guinea pig, ascorbate administration elevated plasma Clq values 30 to 50% over control values. To determine the effects of vitamin supplementation on Clq in man, healthy men and women (n = 14) consumed placebo capsules for 4 weeks and ascorbate supplements, 1500 mg/d, Jor 4 weeks, in a double-blind, cross-over fashion. Subjects ate self-selected diets but were instructed to avoid vitamin C-rich Joods durin~ the 8-week experimental period. Fasting blood samples, collected at the start of the study and at the end of weeks 4 and 8, were analyzed Jbr ascorbate and Clq, measured directly by immunod~ffusion against anti-human Clq. Compared to placebo values, plasma ascorbate rose 92%.[ollowing the 4-week supplementation period, and plasma Clq rose 18%. The rise in Clqfollowing ascorbate administration was not significant (P = 0.12). Furthermore, plasma ascorbate was not correlated with Clq (r = 0.21, P = 0.14). Hence, in healthy men and women, ascorbate supplementation, at levels 25 times that which is recommended, did not significantly alter plasma Clq levels.