Complement Activation in Malaria Immunity and Pathogenesis

✍ Scribed by José A. Stoute

• Publisher: Springer International Publishing
• Year: 2018
• Tongue: English
• Leaves: 154
• Edition: 1st ed.
• Category: Library

✦ Synopsis

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

✦ Table of Contents

Front Matter ....Pages i-xii
The Complement System (Sergei Biryukov, José A. Stoute)....Pages 1-29
Mechanisms of Complement Activation in Malaria (Ronald P. Taylor, José A. Stoute, Margaret A. Lindorfer)....Pages 31-49
Role of Complement in Severe Malarial Anemia (José A. Stoute)....Pages 51-64
Role of Complement in Cerebral Malaria (Theresa N. Schein, Scott R. Barnum)....Pages 65-90
Complement and Malaria in Pregnancy (Andrea Weckman, Vanessa Tran, Kevin C. Kain)....Pages 91-105
Complement Evasion Mechanisms of the Human Pathogen Plasmodium falciparum (Alexander T. Kennedy, Christoph Q. Schmidt, Wai-Hong Tham)....Pages 107-124
Role of Complement in Immunity Against Malaria (José A. Stoute)....Pages 125-137
Complement-Like System in the Mosquito Responses Against Malaria Parasites (Elena A. Levashina, Richard H. G. Baxter)....Pages 139-146
Back Matter ....Pages 147-149

✦ Subjects

Biomedicine; Immunology; Parasitology; Infectious Diseases; Tropical Medicine; Laboratory Medicine