Complement activation, circulating protease inhibitors and pregnancy-associated proteins in severe preeclampsia

Pregnancy-associated plasma protein-A (P

Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells

✍ Kimberly R. Kalli; Bing-Kun Chen; Laurie K. Bale; Erica Gernand; Michael T. Over 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 632 KB

## Abstract Pregnancy‐Associated Plasma Protein‐A (PAPP‐A) proteolyses insulin‐like growth factor binding protein‐4 (IGFBP‐4), thereby regulating local IGF availability. Reduced PAPP‐A mRNA expression has been reported in ovarian cancer specimens compared to normal ovarian surface epithelial cells