## Abstract Fibrinogen adsorption from blood to biomaterials may regulate platelet adhesion and thrombus formation because of fibrinogen's central role in the coagulation cascade and its ability to bind specifically to the platelet membrane glycoprotein (GP) IIbβIIIa. Adsorption of fibrinogen from
Complement activation by hydroxyethylmethacrylate-ethylmethacrylate copolymers
β Scribed by Payne, Mark S. ;Horbett, Thomas A.
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 960 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0021-9304
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Activation of the complement system is one way in which the human body reacts to foreign materials that come in contact with blood. Poly(ethylene oxide) (PEO) has been used quite frequently to modify biomaterial surfaces to prevent protein adsorption and cell adhesion. Despite extensive use of PEO,
## Abstract Nonβspecific activation of complement (NAC) on cell membranes via the alternative pathway was studied by using leukemic cells and cells from a generalized reticulohistiocytosis. The cells were treated with normal human serum in veronalβbuffered saline containing ethyleneglycoltetraβacet