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Complement activation by cytokine-activated neutrophils in the context of Anti-Neutrophil-Cytoplasm Autoantibodies vasculitis

✍ Scribed by M. Frimat; L. Camous; L. Roumenina; S. Bigot; P. Lesavre; V. Fremeaux-Bacchi; L. Halbwachs-Mecarelli


Book ID
116757383
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
79 KB
Volume
46
Category
Article
ISSN
0161-5890

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## Background: Anti-neutrophil cytoplasmic autoantibodies (anca) induce neutrophil activation in vitro with release of injurious products that can mediate necrotizing vasculitis in vivo. the importance of anca igg f(ab')2-antigen binding versus fcgamma receptor engagement in this process is controv