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Competitive inhibition of photoaffinity labelling of P-glycoprotein by anticancer drugs and modulators including S9788

✍ Scribed by Annette Demmer; Theresa Dunn; Torsten Hoof; Peter Kubesch; Burkhard Tümmler

Book ID: 117098783
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 536 KB
Volume: 315
Category: Article
ISSN: 0014-2999
DOI: 10.1016/s0014-2999(96)00616-4

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## Abstract The P‐glycoprotein (p170, P‐gp) encoded by human __MDR1__ gene functions as a pump to extrude anticancer drugs from cancer cells. Over‐expression of p170 is closely related to primary and induced drug resistance phenotype of tumor cells. Recent studies have demonstrated that expression