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Competitive inhibition of corticoid synthesis by estrogens

โœ Scribed by Kenneth W Mckerns


Book ID
115792018
Publisher
Elsevier Science
Year
1963
Weight
257 KB
Volume
69
Category
Article
ISSN
0006-3002

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Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups