Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

✍ Scribed by H. S. Micklem; C. E. Ford; E. P. Evans; D. A. Ogden; D. S. Papworth

• Book ID: 102309186
• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 449 KB
• Volume: 79
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040790214

✦ Synopsis

The relative proliferative capacity of haematopoietic cell populations derived from 22-week-old adult bone marrow and 14-18 day foetal liver has been studied i n lethally irradiated syngeneic recipients by means of chromosome markers. Although starting a t a disadvantage i n terms of the number of colony-forming units (stem cells) injected, the foetal liver-derived populations steadily increased their relative numbers i n the myeloid and lymphoid tissues over a period of several weeks until a plateau was reached. It is suggested that stem cells in foetal liver have, on average, a higher intrinsic capacity for self-renewal than do those i n bone marrow, falls to the adult level within about ten weeks of transfer.