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Competitive Coexistence in Antiviral Immunity

✍ Scribed by RAMY A. ARNAOUT; MARTIN A. NOWAK

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 216 KB
Volume: 204
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.2000.2027

No coin nor oath required. For personal study only.

✦ Synopsis

Adaptive immunity to viruses in vertebrates is mediated by two distinct but complementary branches of the immune system: the cellular response, which eliminates infected cells, and the humoral response, which eliminates infectious virus. This leads to an interesting contest, since the two responses compete, albeit indirectly, for proliferative stimuli. How can a host mount a coordinated antiviral campaign? Here we show that competition may lead to a state of &&competitive coexistence'' in which, counterintuitively, each branch complements the other, with clinical bene"t to the host. The principle is similar to free-market economics, in which "rms compete, but the consumer bene"ts. Experimental evidence suggests this is a useful paradigm in antiviral immunity.

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