Compatibility of organic solvents with the Salmonella/microsome test

✍ Scribed by Dorothy Maron; John Katzenellenbogen; Bruce N. Ames

• Book ID: 119092239
• Publisher: Elsevier Science
• Year: 1981
• Tongue: English
• Weight: 499 KB
• Volume: 88
• Category: Article
• ISSN: 0165-1218
• DOI: 10.1016/0165-1218(81)90025-2

✦ Synopsis

We have screened 14 solvents for compatibility with the Salmonella mutagenicity test and have found 12 to be satisfactory under the conditions specified. These 12 solvents are: dimethyl sulfoxide, glycerol formal, dimethyl formamide, formamide, acetonitrile, 95% ethanol, acetone, ethylene glycol dimethyl ether, 1-methyl-2-pyrrolidinone, p-dioxane, tetrahydrofurfuryl alcohol and tetrahydrofuran.

The influence of the nutrient broth culture medium on the spontaneous mutation rate of the tester strains is also discussed.