Compartmentalized, multiphasic nanocolloids with potential applications in drug delivery and biomedical imaging

✍ Scribed by K.-H. Roh; M. Yoshida; J. Lahann

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 174 KB
• Volume: 38
• Category: Article
• ISSN: 0933-5137
• DOI: 10.1002/mawe.200700245

✦ Synopsis

Abstract

Nanoparticles are excellent candidates for drug delivery or biomedical imaging, because they often exhibit superb tuneability of critical properties, such as size, surface characteristics, degradation rate, and therefore drug release rates. We have recently developed a route towards fabrication of sub‐micron particles that relies on electrohydrodynamic co‐jetting. In this process, fluid manipulation in an electrical field is used to fabricate large quantities of multi‐compartment particles, where individual compartments can be independently loaded with different drugs or selectively surface‐modified. In this contribution, aspects of multifunctional particles for biomedical applications are reviewed and a specific focus is given to recent progress with compartmentalized, multiphasic nanocolloids in our laboratory.