Comparisons of pKa and log P values of some carboxylic and phosphonic acids: Synthesis and measurement
β Scribed by Franz, Robert G.
- Book ID
- 118728936
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 732 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1530-9932
- DOI
- 10.1208/ps030210
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π SIMILAR VOLUMES
## Abstract For optimization of liquid chromatography separations, several approaches have been reported, among them the use of the hydrophobic fragmental constant, as proposed by __Rekker__ [1]. The fragmental constant is derived from the partition coefficients of various solutes between octanol a
## 3. VIII.92) (o-Hydroxypheny1)methylphosphonic acids are readily obtained from o-(bromomethy1)or o-(hydroxy-methy1)phenols and trialkyl phosphites. Subsequent hydrolysis leads to the corresponding phosphonic acids. For a series of such compounds, the pK, values have been determined by potentiomet