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Comparisons between operant response and 1,1,1-trichloroethane toxicokinetics in mouse blood and brain

✍ Scribed by Li You; Srinivasa Muralidhara; Cham E. Dallas


Book ID
107938950
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
896 KB
Volume
93
Category
Article
ISSN
0300-483X

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Permeability data from MDR1-MDCKII and PAMPA-BBB assays were compared to data from in situ brain perfusion to evaluate the accuracy of in vitro assays in predicting in vivo blood-brain barrier (BBB) permeability. PAMPA-BBB significantly correlated to in situ brain perfusion, however, MDR1-MDCKII had