Comparison of whole-body liquid scintillometry, radiography, and clinical chemical tests in the evaluation of the effect of chronic corticoid dosing on calcium in beagles
✍ Scribed by M. C. Bhatti; S. M. Shaw; R. E. Lewis; J. E. Christian
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 477 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
Chronic doses of 6a-methylprednisolone were administered to beagles for 106 days to bring about changes in calcium balance. During the initial 64 days of corticoid treatment, no outstanding changes were observed in the blood levels of calcium, phosphorus, or alkaline phosphatase. Radiographic changes in the skeleton were not seen after 64 days of treatment. Significant changes in 47Ca retention were detected by whole-body liquid scintillometry after only 13 and 28 days of corticoid administration. On day 64 of the study, the dosage of 6a-methylprednisolone was increased. Decreased levels of calcium in blood plasma and increased levels of plasma alkaline phosphatase were observed after the dose of corticoid was increased. A great reduction in whole-body 47Ca retention was also observed, and thinning of the cortices of the long bones of the legs was apparent. The results of the investigation indicate that whole-body liquid scintillation counting of T a is a sensitive indicator of alterations of calcium metabolism in relation to other diagnostic methodology.