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Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities

✍ Scribed by Terrence W. Hallahan; David A. Krantz; Lucia Tului; Ezio Alberti; Philip D. Buchanan; Francesco Orlandi; Victor Klein; John W. Larsen Jr; James N. Macri

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 174 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199809)18:9<893::aid-pd362>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

To evaluate the potential utility of free beta (hCG) and beta-core (hCG) in a prenatal screening protocol for Down syndrome we analysed these markers in dried maternal urine specimens from 163 control, 13 Down syndrome and 5 trisomy 18 pregnancies from 8 to 25 weeks' gestation. All results are reported after normalization for urinary creatinine determined by modified Jaffe reagent assay. The correlation of urinary free beta (hCG) and urinary beta-core (hCG) was 0•61 in controls and 0•93 in Down syndrome. Median MoM values in Down syndrome were 2•42 for urinary free beta (hCG) and 2•40 for beta-core (hCG). In trisomy 18 the median MoM was 0•35 and 0•34 for free beta (hCG) and beta-core (hCG), respectively. The degree of elevation observed in DS cases with urinary free beta (hCG) is consistent with previous reports. Studies of beta-core (hCG) in Down syndrome have yielded discrepant results. In this study, beta-core (hCG) in Down syndrome is lower than values observed in early reports but consistent with more recent reports.

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