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Comparison of urinary 6-β-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

✍ Scribed by Guzelian, Philip S; Voorhees, John J; Watkins, Paul B; Turgeon, D Kim; Saenger, Paul; Lown, Kenneth S; Kolars, Joseph C; Hamilton, Ted; Fishman, Kenneth


Book ID
109845112
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
684 KB
Volume
52
Category
Article
ISSN
0009-9236

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Assessment of ifosfamide pharmacokinetic
✍ Rashmi Chugh; Thomas Wagner; Kent A. Griffith; Jeremy M.G. Taylor; Dafydd G. Tho 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was