Comparison of two inbred strains of mice and their F1 hybrid in response to androgen

✍ Scribed by Chai, C. K.

• Publisher: John Wiley and Sons
• Year: 1956
• Tongue: English
• Weight: 651 KB
• Volume: 126
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1091260302

✦ Synopsis

The choice between use of the hybrid or inbred animal in bioassay has lately become a matter of great concern. There are two important biological phenomena which seen to underly such considerations. One is heterosis, which has long been applied to animal and plant breeding. The other is the possibility of a superior buffering property o r autoregulating power of the heterozygous individuals recently described by Lerner ( '54) as genetic homeostasis which consequentially would lead to less variability. How might these phenomena be involved in biological response in a bioassay? Does the conventional belief that more accurate and repeatable experimental results can be expected by using inbred animals require modification? These are some of the questions, which this study attempts to answer.

There have been many studies on this subject reported in the past. However, the amount of attention has recently been intensified. Emmens ('39) found individuals from an inbred strain of mice, CBA, to be more variable in response to estrogen stimulation than those from a randomly bred stock. Shim-