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Comparison of two dissolution apparatuses with correlation of in vitro-in vivo data for prednisone and prednisolone tablets

✍ Scribed by Rebecca L. Milsap; James W. Ayres; Janis J. Mackichan; John G. Wagner

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 618 KB
Volume: 1
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510010103

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Dissolution profiles in 0‐1N hydrochloric acid using both the paddle stirrer apparatus and the spin filter apparatus were obtained for prednisone tablets made by seven different manufacturers and prednisolone tablets made by eight different manufacturers. Dissolution parameters were correlated with results obtained in three human bioavailability trials which were previously reported. Also, results obtained in one apparatus were correlated with those obtained in the other apparatus. Such correlations may be useful in the setting of in vitro dissolution rate specifications for commercial prednisone and prednisolone tablets.

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