๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Comparison of two 99mTc(V)-dimercaptosuccinic acid preparations

โœ Scribed by O. Jeghers; N. Puttemans; D. Urbain; J. Lefebvre; H.R. Ham

Publisher
Elsevier Science
Year
1987
Weight
843 KB
Volume
38
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

โœฆ Synopsis

99mTc(V)-DMSA labelled either by increasing the pH together with a low concentration of Sn, or by increasing the pH only are compared in vitro and in vivo. The gel chromatographic separation shows that after incubation with blood, all the 99mTc(V)-DMSA preparations are stable and do not bind to the plasma proteins. The behavior in rats as well as in clinical studies does not demonstrate any distinctive characteristics between the different radiomolecules. It seems that the pH of the solution is an important factor which controls the formation of 99mTc(V)-DMSA.

๐Ÿ“œ SIMILAR VOLUMES

A clinical comparison of99mTc-DPD and tw
A clinical comparison of99mTc-DPD and two99mTc-MDP agents
โœ M. Vorne; S. Vรคhรคtalo; T. Lantto ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 308 KB

Two hundred and fifty-seven patients were studied with bone-seeking radiopharmaceuticals. They were randomly divided into three groups. Two groups were injected with two different 99mTc-methylene diphosphonates from two manufacturers (MDP 1 and MDP 2) and the third group with 99mTc-dicarboxypropane

Studies of chemical and biological prope
Studies of chemical and biological properties of99mTc-DMS (dimercaptosuccinic acid) โ€” Renal imaging agent
โœ Nada M. Vanliฤ‡-Razumeniฤ‡; Daroslava A. Gorkiฤ‡ ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 711 KB

Studies of the chemistry of preparation of tin chelate 2.3-dimercaptosuccinic acid (DMS) complexed with 99mTc with respect to its biological properties have been made. We have varied molar ratio of reactants (DMS:Sn/II/), concentration of Sn-DMS chelate and pH of 99mTc-DMS injection solution and exa