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Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats

✍ Scribed by Xue, Mei; Zhao, Yan; Li, Xue-jun; Jiang, Zhen-zhou; Zhang, Liang; Liu, Su-huan; Li, Xiu-min; Zhang, Lu-Yong; Yang, Shu-yu

Book ID
118240912
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
480 KB
Volume
47
Category
Article
ISSN
0928-0987

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Idarubicin-loaded solid lipid nanoparticles (IDA-SLN) and idarubicin in solution were prepared and the two formulations were administered to rats, either by the duodenal route or intravenously (iv). The aim of this research was to study whether the bioavailability of idarubicin can be improved by ad