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Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice

✍ Scribed by Mohammed, Wasseem; Alhaddad, Hisham; Marie, Nicolas; Tardy, Floriane; Lamballais, Florence; Risède, Patricia; Noble, Florence; Baud, Frédéric J.; Mégarbane, Bruno

Book ID: 121392576
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 536 KB
Volume: 217
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2012.12.021

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## Abstract A single injection of morphine or isotonic saline was administered to rats at either 1, 5, 9, or 13 days of age. At 26–29 days of age, animals were tested for pain responsivity and activity following either morphine (5 mg/kg) or saline. Animals which received morphine at 1 day of age di