𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Comparison of three prophylactic antibiotic regimens in clean-contaminated head and neck surgery

✍ Scribed by Juan P. Rodrigo; Juan C. Alvarez; Justo R. Gómez; Carlos Suárez; José A. Fernández; José A. Martínez

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
140 KB
Volume
19
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Although appropriate perioperative antibiotic prophylaxis has significantly reduced wound infection rates in clean-contaminated head and neck surgical procedures, controversy still remains regarding the optimal antibiotic regimen.

Methods:

In this prospective, double-blind clinical trial, 159 patients were randomized to receive amoxicillin-clavulanate, clindamycin plus gentamicin, or cefazolin intravenously up to 1/2 hour before surgery and at 6-hour intervals for an additional three doses.

Results:

An overall wound infection rate of 23% was observed. thirteen (22.8%) infections occurred in the amoxicillin-clavulanate-treated group, 11 (21.2%) in the clindamycin plus gentamicin-treated group, and 13 (26%) in the cefazolin-treated group, which was not statistically significant. only prior medical illnesses, such as chronic obstructive pulmonary disease and diabetes mellitus, correlated with an increased wound infection rate (p = 0.018).

Conclusions:

Amoxicillin-clavulanate, clindamycin plus gentamicin, and cefazolin seem to have similar efficacy when administered prophylactically in clean-contaminated head and neck surgical procedures.

📜 SIMILAR VOLUMES

Induction therapy in head and neck cance
Induction therapy in head and neck cancer. A comparison of two regimens
✍ Monica Spaulding; Patricia Ziegler; Nan Sundquist; Douglas Klotch; Keun Lee; Anj 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB 👁 2 views

Seventy-two patients with advanced resectable head and cancer received two courses of induction chemotherapy before definitive therapy. Forty-six patients were treated with platinol, Oncovin (vincristine), and bleomycin. Twenty-six received Platinol (cisplatin), Velban (vinblastine), and 5-fluoroura

Comparison of ampicillin/sulbactam versu
Comparison of ampicillin/sulbactam versus clindamycin in the prevention of infection in patients undergoing head and neck surgery
✍ Jonas T. Johnson; Kim Kachman; Robin L. Wagner; Eugene N. Myers 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 153 KB 👁 1 views

Background. Patients requiring major oncologic head and neck surgery are at high risk for postoperative wound infection when the surgical site is contaminated by secretions from the upper aerodigestive tract. Studies to identify agents active in the prevention of postoperative wound infection may se

Manual of surgery. By Alexis Thomson, F.
Manual of surgery. By Alexis Thomson, F.R.C.S., Professor of Surgery, University of Edinburgh, Surgeon to the Royal Infirmary, Edinburgh; and Alexander Miles, F.R.C.S., Surgeon to the Royal Infirmary, Edinburgh. Sixth edition. In three volumes. Vol I, General Surgery, pp. 565, figs. 169. Vol. II, Extremities, Head and Neck. pp. 659, figs. 288. Vol. III, Thorax and Abdomen, pp. 566, figs. 161. 1921. London: Henry Frowde and Hodder & Stoughton. Vol. III. 12s. 6d. net
📂 Article 📅 1922 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views