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Comparison of the Vβ Repertoire in Peripheral Blood and in Lymph Nodes of HIV-Infected Subjects Reveals Skewed Usage Predominantly in CD8+T Cells

✍ Scribed by Maurizio Carbonari; Marina Cibati; Anna M. Pesce; Lucia Dell’anna; Giampiero D'offizi; Alberto Angelici; Stefania Uccini; Massimo Fiorilli


Book ID
112240899
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
213 KB
Volume
81
Category
Article
ISSN
1090-2341

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The antigenic specificity of the majority of T lymphocytes in the peripheral blood is determined by the combination of a and p variable region chains present in the T cell receptor complex. Currently, the Vp chains are grouped into 25 families. Historically, determination of Vp usage has relied on d