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Comparison of the stepwise and convergent approaches in the solid-phase synthesis of rat Tyro-atriopeptin II

✍ Scribed by Dimitrios Gatos; Stella Patrianakou; Olga Hatzi; Kleomenis Barlos


Book ID
105576477
Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
446 KB
Volume
4
Category
Article
ISSN
1573-3149

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## Abstract The RING finger domain of the Mdm2, located at the __C__‐terminus of the protein, is necessary for regulation of p53, a tumor suppressor protein. The 48‐residues long Mdm2 peptide is an important target for studying its interaction with small anticancer drug candidates. For the chemical