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Comparison of the Neutralizing and ELISA Antibody Titres to Human Cytomegalovirus (HCMV) in Human Sera and in Gamma Globulin Preparations

✍ Scribed by Dr. Herbert Schmitz And; Suliman Essuman

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 355 KB
Volume: 20
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890200209

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✦ Synopsis

Administration of anti-cytomegalovirus gamma globulin has been reported to prevent acute human cytomegalovirus (HCMV) infection in immunocompromised patients. Most likely the gamma globulin acts by its neutralizing activity. However, the antibody titer to HCMV in hyperimmune gamma globulin is usually detected by an enzyme immunoassay (ELISA). We, therefore, compared the ELISA titres with the neutralizing antibody titres in the sera of blood donors and in hyperimmune gamma globulins. A poor correlation between both titres was found. Gamma globulin preparations with identical ELISA titres clearly differed in the neutralizing titre. If neutralization is the important mechanism by which the hyperimmune gamma globulins work, our results would favour a routine testing of the neutralizing antibody titre in HCMV hyperimmune gamma globulins.

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Lack of association between the kinetics of human cytomegalovirus (HCMV) glycoprotein B (gB)-specific and neutralizing serum antibodies and development or recovery from HCMV active infection in patients undergoing allogeneic stem cell transplant

✍ Isabel Muñoz; Antonio Gutiérrez; Concepción Gimeno; Amparo Farga; Juan Alberola; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB

The kinetics of the gB-specific and neutralizing antibody responses to human cytomegalovirus (HCMV) were analyzed in 26 allogeneic stem-cell transplant recipients who either did (n = 20) or did not (n = 6) develop asymptomatic HCMV active infection during the study period. Antibody response profiles